Phenotypes Associated with This Genotype

Genotype
MGI:5781008

• Allelic Composition: Slitrk3^tm1Jaru/Slitrk3^tm1Jaru
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:232385 )

N • mice exhibit normal gross brain morphology and miniature excitatory postsynaptic currents (frequency and amplitude)

seizures ( J:232385 )

• spontaneous seizures

increased susceptibility to pharmacologically induced seizures ( J:232385 )

• reduced inhibitory synapse density compared with wild-type mice

abnormal synapse morphology ( J:232385 )

• reduced inhibitory synapse density compared with wild-type mice

decreased miniature inhibitory postsynaptic current frequency ( J:232385 )

• decreased frequency, but not amplitude, compared with wild-type mice

behavior/neurological

seizures ( J:232385 )

• spontaneous seizures

increased susceptibility to pharmacologically induced seizures ( J:232385 )

• reduced inhibitory synapse density compared with wild-type mice