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Phenotypes Associated with This Genotype
Genotype
MGI:5780072
Allelic
Composition		 Kmt2dtm1.1Kaig/Kmt2d+
Ighg1tm1(cre)Cgn/Ighg1+
Tg(Vav-BCL2)69Jad/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (4 available); any Ighg1 mutation (30 available)
Kmt2dtm1.1Kaig mutation (1 available); any Kmt2d mutation (171 available)
Tg(Vav-BCL2)69Jad mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:228913 )
• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm
increased B cell derived lymphoma incidence ( J:228913 )
• diffuse large B cell lymphoma as in Tg(Vav-BCL2)1Jad mice
increased follicular lymphoma incidence ( J:228913 )
• more so than in Tg(Vav-BCL2)1Jad mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory