About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5780067
Allelic
Composition		 Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Kmt2dtm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:228913 )
N
• unimmunized mice exhibit normal numbers of bone marrow B cell subpopulations, splenic follicular B cells and marginal zone B cells
• mice immunized with sheep red blood cell exhibit normal numbers of transitional and marginal zone B cells
abnormal B cell differentiation ( J:228913 )
• modest impairment in affinity maturation
• however, somatic hypermutation is normal
increased germinal center B cell number ( J:228913 )
• 3-fold in the spleen and also in the mesenteric lymph nodes of mice immunized with sheep red blood cell
• in mice challenged with NP-KLH
decreased B cell number ( J:228913 )
• in the spleen and lymph nodes of mice immunized with sheep red blood cell
decreased mature B cell number ( J:228913 )
• in the bone marrow of mice immunized with sheep red blood cell
increased spleen germinal center number ( J:228913 )
• in mice immunized with sheep red blood cell
• in mice challenged with NP-KLH
increased spleen germinal center size ( J:228913 )
• in mice immunized with sheep red blood cell
• in mice challenged with NP-KLH
decreased IgG1 level ( J:228913 )
• 10-fold less in mice challenged with NP-KLH
decreased IgM level ( J:228913 )
• 10-fold less in mice challenged with NP-KLH

hematopoietic system
abnormal B cell differentiation ( J:228913 )
• modest impairment in affinity maturation
• however, somatic hypermutation is normal
increased germinal center B cell number ( J:228913 )
• 3-fold in the spleen and also in the mesenteric lymph nodes of mice immunized with sheep red blood cell
• in mice challenged with NP-KLH
decreased B cell number ( J:228913 )
• in the spleen and lymph nodes of mice immunized with sheep red blood cell
decreased mature B cell number ( J:228913 )
• in the bone marrow of mice immunized with sheep red blood cell
increased spleen germinal center number ( J:228913 )
• in mice immunized with sheep red blood cell
• in mice challenged with NP-KLH
increased spleen germinal center size ( J:228913 )
• in mice immunized with sheep red blood cell
• in mice challenged with NP-KLH
decreased IgG1 level ( J:228913 )
• 10-fold less in mice challenged with NP-KLH
decreased IgM level ( J:228913 )
• 10-fold less in mice challenged with NP-KLH

cellular

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory