Phenotypes Associated with This Genotype

Genotype
MGI:5779302

• Allelic Composition: Anks1b^tm1Bnaj/Anks1b^tm1Bnaj; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:222552 )

N • CA1 pyramidal cell synapses exhibit normal input-output function with normal amplitudes or frequencies of AMPAR-mediated miniature excitatory postsynaptic currents

impaired synaptic plasticity ( J:222552 )

• impaired NMDAR-dependent synaptic plasticity at hippocampal Sch-CA1 synapses

short excitatory postsynaptic current decay time ( J:222552 )

• faster decay of NMDAR-mediated excitatory postsynaptic currents

• reduced sensitivity to Ro25-6981 but increased sensitivity to low doses of zinc, which selectively blocks GluN2B-containing and GluN2A-containing NMDARs

reduced long-term depression ( J:222552 )

• reduced NMDAR-dependent long term depression

• however, mGluR(Grm8)-dependent LTD is not affected