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Phenotypes Associated with This Genotype
Genotype
MGI:5771655
Allelic
Composition		 \Brip1Gt(RRI409)Byg/\Brip1Gt(RRI409)Byg
\Fancd2tm1Hou/\Fancd2tm1Hou
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brip1Gt(RRI409)Byg mutation (0 available); any Brip1 mutation (65 available)
Fancd2tm1Hou mutation (0 available); any Fancd2 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal seminiferous tubule morphology ( J:227115 )
• histology revealed significantly more atrophic seminiferous tubules relative to single homozygotes and wild-type controls
• atrophic tubules are mostly devoid of spermatogenic cells and composed of Sertoli cells only
small testis ( J:227115 )
• double mutants show significantly smaller testes than wild-type controls

cellular
increased cellular sensitivity to DNA damaging agents ( J:227115 )
• unexpectedly, MEFs derived from double homozygotes are significantly more sensitive to mitomycin C than either single homozygote

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:227115 )
• histology revealed significantly more atrophic seminiferous tubules relative to single homozygotes and wild-type controls
• atrophic tubules are mostly devoid of spermatogenic cells and composed of Sertoli cells only
small testis ( J:227115 )
• double mutants show significantly smaller testes than wild-type controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory