Analysis Tools
normal phenotype
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• kinase-inactive homozygotes are viable and develop normally with no significant differences in body weight, food intake, general locomotor activity or serum total Mg2+ and Ca2+ levels relative to wild-type controls
• although basal native channel activity is significantly increased prior to cytoplasmic Mg2+ depletion, maximal current density measured after Mg2+ depletion is not significantly altered in peritoneal macrophages, indicating normal native channel function
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