Phenotypes Associated with This Genotype

Genotype
MGI:5770438

• Allelic Composition: Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺; Tg(RasE)290Biat/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased sebaceous gland tumor incidence ( J:226601 )

• about 80% of tamoxifen-injected mice develop tumors in the skin which immunohistochemistry suggests are skin-appendage tumors derived from sebaceous glands

• skin-appendage tumors develop when 4-OH tamoxifen is applied atopically onto the back of the skin; 98.3% of tumors show simultaneous activation of the three alleles

increased pancreas tumor incidence ( J:226601 )

• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection

increased pancreatic ductal adenocarcinoma incidence ( J:226601 )

• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

increased pancreatic intraepithelial neoplasia incidence ( J:226601 )

• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

increased lung tumor incidence ( J:226601 )

• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection

increased lung adenocarcinoma incidence ( J:226601 )

• lung tumors of tamoxifen treated mice are adenocarcinomas

endocrine/exocrine glands

increased sebaceous gland tumor incidence ( J:226601 )

• about 80% of tamoxifen-injected mice develop tumors in the skin which immunohistochemistry suggests are skin-appendage tumors derived from sebaceous glands

• skin-appendage tumors develop when 4-OH tamoxifen is applied atopically onto the back of the skin; 98.3% of tumors show simultaneous activation of the three alleles

increased pancreas tumor incidence ( J:226601 )

• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection

increased pancreatic ductal adenocarcinoma incidence ( J:226601 )

• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

increased pancreatic intraepithelial neoplasia incidence ( J:226601 )

• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

respiratory system

increased lung tumor incidence ( J:226601 )

• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection

increased lung adenocarcinoma incidence ( J:226601 )

• lung tumors of tamoxifen treated mice are adenocarcinomas

integument

increased sebaceous gland tumor incidence ( J:226601 )

• about 80% of tamoxifen-injected mice develop tumors in the skin which immunohistochemistry suggests are skin-appendage tumors derived from sebaceous glands

• skin-appendage tumors develop when 4-OH tamoxifen is applied atopically onto the back of the skin; 98.3% of tumors show simultaneous activation of the three alleles