Phenotypes Associated with This Genotype

Genotype
MGI:5762869

• Allelic Composition: Ruvbl1^tm1.1Oxbk/Ruvbl1^tm1.1Oxbk; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:220926 )

• rapid decline in survival with complete lethality observed at 2 weeks after polyIC induction, associated with a significant decrease in peripheral blood cells

hematopoietic system

abnormal definitive hematopoiesis ( J:220926 )

• complete hematopoietic failure on day 8 after first polyIC injection

decreased bone marrow cell number ( J:220926 )

• on day 8 after first polyIC injection, surviving mice show massive loss of bone marrow cellularity, involving coordinated loss of myeloid (Mac-1+) and lymphoid (B220+) cells

absent hematopoietic stem cells ( J:220926 )

• complete loss of Lin^-Sca-1⁺c-Kit⁺ (LSK) hematopoietic stem cells in the bone marrow on day 8 after first polyIC injection

pancytopenia ( J:220926 )

• death at 2 weeks after polyIC induction is associated with pancytopenia

abnormal hematopoietic stem cell physiology ( J:220926 )

• competitive repopulation experiments revealed loss of hematopoietic stem cells through apoptosis

bone marrow failure ( J:220926 )

• bone marrow failure characterized by apoptotic loss of hematopoietic stem cells on day 8 after first polyIC injection

immune system

bone marrow failure ( J:220926 )

• bone marrow failure characterized by apoptotic loss of hematopoietic stem cells on day 8 after first polyIC injection