Phenotypes Associated with This Genotype

Genotype
MGI:5762856

• Allelic Composition: Riox1^tm1Qch/Riox1^tm1Qch; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

thick neurocranium ( J:224562 )

• thicker than in control mice

increased width of hypertrophic chondrocyte zone ( J:224562 )

• at E14.5 and E15.5 in the femur

abnormal bone structure ( J:224562 )

enhanced osteoblast differentiation ( J:224562 )

• increased Sp7+ preosteoblasts and osteoblasts in endochondral and membranous bones

decreased osteoclast cell number ( J:224562 )

increased bone mineral density ( J:224562 )

• at 2 months of age

increased bone volume ( J:224562 )

• at 2 months of age

increased compact bone thickness ( J:224562 )

• at 2 months of age

increased osteoblast cell number ( J:224562 )

increased bone trabecula number ( J:224562 )

• in the femur

increased bone mass ( J:224562 )

abnormal bone ossification ( J:224562 )

• larger primary ossification centers at E14.5 and E15.5 in the femur compared with wild-type mice

abnormal endochondral bone ossification ( J:224562 )

• increased ossification in the limbs

abnormal intramembranous bone ossification ( J:224562 )

• increased ossification in the skull

growth/size/body

increased birth weight ( J:224562 )

increased body weight ( J:224562 )

• at 2 months of age

increased body length ( J:224562 )

• in newborns and at 2 months of age

craniofacial

thick neurocranium ( J:224562 )

• thicker than in control mice

cellular

enhanced osteoblast differentiation ( J:224562 )

• increased Sp7+ preosteoblasts and osteoblasts in endochondral and membranous bones

hematopoietic system

decreased osteoclast cell number ( J:224562 )

immune system

decreased osteoclast cell number ( J:224562 )