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Phenotypes Associated with This Genotype
Genotype
MGI:5759821
Allelic
Composition
Trp53tm3Tyj/Trp53+
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (191 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy
• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks
• mammary tumors of both untreated and DMBA-treated mice are heterogeneous, including frequent adenocarcinomas, solid carcinomas, papillary carcinomas, and adenosquamous carcinomas, carcinosarcomas and sarcomas
• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive
• 40% of females exposed to DMBA for 6 weeks develop mammary tumors, with a mean latency time of 8.5 +/- 4.7 weeks
• females exposed to DMBA also develop lymphomas, ovary, lung, stomach, uterus and skin tumors
• some mice develop an additional lymphoma
• some mice develop an additional sarcoma in the abdomen
• some mice develop an additional tumor of the lung

mortality/aging
• premature death, with only 2 of 11 mice surviving past 78 weeks

endocrine/exocrine glands
• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy
• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks
• mammary tumors of both untreated and DMBA-treated mice are heterogeneous, including frequent adenocarcinomas, solid carcinomas, papillary carcinomas, and adenosquamous carcinomas, carcinosarcomas and sarcomas
• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive

homeostasis/metabolism
• 40% of females exposed to DMBA for 6 weeks develop mammary tumors, with a mean latency time of 8.5 +/- 4.7 weeks
• females exposed to DMBA also develop lymphomas, ovary, lung, stomach, uterus and skin tumors

integument
• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy
• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks
• mammary tumors of both untreated and DMBA-treated mice are heterogeneous, including frequent adenocarcinomas, solid carcinomas, papillary carcinomas, and adenosquamous carcinomas, carcinosarcomas and sarcomas
• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive

respiratory system
• some mice develop an additional tumor of the lung

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:101617


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory