Analysis Tools
homeostasis/metabolism
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• decreased platelet life span in vivo resulting in increased turnover
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• moderate decrease following activation with integrin alpha2bbeta3
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• at low agonist concentrations (thromboxane A2 analog U46619, CRP, and collagen) with increased aggregate size
• however, aggregation is normal in response to thrombin and do not exhibit spontaneous aggregation upon addition of epinephrine
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• upon agonist activation, platelets exhibit moderately increased secretion compared with control cells
• in response to thrombin and CRP, ATP release is strongly increased compared to in control cells
• however, cells exhibit normal serotonin release and numbers of alpha and dense granules
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• accelerated arterial occlusive thrombus formation following ferric chloride-induced mesenteric arteriole injury
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hematopoietic system
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• increased platelet size determined by increased width
• reduced filopodia extension after adhesion of immobilized VWF
• however, mice exhibit normal formation and structure of filopodia and normal spreading morphology following activation with ADP or thrombin
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• moderate
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• decreased platelet life span in vivo resulting in increased turnover
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• moderate decrease following activation with integrin alpha2bbeta3
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• at low agonist concentrations (thromboxane A2 analog U46619, CRP, and collagen) with increased aggregate size
• however, aggregation is normal in response to thrombin and do not exhibit spontaneous aggregation upon addition of epinephrine
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• upon agonist activation, platelets exhibit moderately increased secretion compared with control cells
• in response to thrombin and CRP, ATP release is strongly increased compared to in control cells
• however, cells exhibit normal serotonin release and numbers of alpha and dense granules
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