Phenotypes for Nlgn2 Nlgn3 Tg(Pcp2-cre)2Mpin MGI:5754962 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn2^tm1.1Sud mutation (1 available); any Nlgn2 mutation (34 available)
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (35 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:227671 )

N	• no change in parallel fiber synpatic transmission

abnormal synapse morphology ( J:227671 )

• slight decrease in climbing-fiber synapse (vGluT2 staining) cluster density and size

decreased excitatory postsynaptic current amplitude ( J:227671 )

• decrease in climbing-fiber EPSC amplitude, but no change in quantal events

abnormal miniature inhibitory postsynaptic currents ( J:227671 )

• large decrease in frequency (90%) and amplitude (45%) of mIPScs

decreased miniature inhibitory postsynaptic current amplitude ( J:227671 )

• 45% decrease

decreased miniature inhibitory postsynaptic current frequency ( J:227671 )

• 90% decrease

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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