About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5754948
Allelic
Composition		 Nlgn1tm1.1Sud/Nlgn1tm1.1Sud
Nlgn3tm4.1Sud/Y
Tg(Pcp2-cre)2Mpin/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn1tm1.1Sud mutation (0 available); any Nlgn1 mutation (63 available)
Nlgn3tm4.1Sud mutation (0 available); any Nlgn3 mutation (34 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:227671 )
N
• no change in parallel fiber synpatic transmission
• no change in basket/stellate cell synapse-mediated mIPSCs
abnormal synapse morphology ( J:227671 )
• 5% loss of distal climbing-fiber synapse numbers
• 25% decrease in synapse size
decreased excitatory postsynaptic current amplitude ( J:227671 )
• modest decrease (10%) in climbing fiber synapse EPSC amplitude
• no change in paired pulse ratio is detected or synapse elimination

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory