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Phenotypes Associated with This Genotype
Genotype
MGI:5754385
Allelic
Composition		 Psen1tm2Shn/Psen1tm4.1Shn
Psen2tm1Haa/Psen2tm1Haa
Tg(Camk2a-cre)1Shn/0
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2Shn mutation (1 available); any Psen1 mutation (46 available)
Psen1tm4.1Shn mutation (0 available); any Psen1 mutation (46 available)
Psen2tm1Haa mutation (0 available); any Psen2 mutation (31 available)
Tg(Camk2a-cre)1Shn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
microgliosis ( J:219929 )
• in the neocortex and hippocampus
abnormal cerebral cortex morphology ( J:219929 )
• 31.5% reduction in cortical volume at 18 months of age
abnormal neocortex morphology ( J:219929 )
• increase in apoptosis in the neocortex
astrocytosis ( J:219929 )
• in the cortex
decreased neuron number ( J:219929 )
• 22.1% reduction in neuron number in the cerebral cortex at 18 months of age
neurodegeneration ( J:219929 )
• mice exhibit age-dependent neurodegeneration throughout the cerebral cortex

hematopoietic system
microgliosis ( J:219929 )
• in the neocortex and hippocampus

immune system
microgliosis ( J:219929 )
• in the neocortex and hippocampus

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:219929

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory