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Phenotypes Associated with This Genotype
Genotype
MGI:5752190
Allelic
Composition		 Ptentm2Mak/Ptentm2Mak
Tg(Wap-cre)11738Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2Mak mutation (4 available); any Pten mutation (87 available)
Tg(Wap-cre)11738Mam mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:224955 )
• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance
• nearly all mice succumb to cancer by 18 months of age
increased mammary adenocarcinoma incidence ( J:224955 )
• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma
increased mammary gland tumor incidence in breeding females ( J:224955 )
• pregnancy accelerates tumor formation
increased spindle cell carcinoma incidence ( J:224955 )
• 3% of mammary tumors are spindle-cell/adenosarcoma
increased myoepithelioma incidence ( J:224955 )
• 70% of mammary tumors are adenomyoepithelioma

integument
increased mammary gland tumor incidence ( J:224955 )
• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance
• nearly all mice succumb to cancer by 18 months of age
increased mammary adenocarcinoma incidence ( J:224955 )
• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma
increased mammary gland tumor incidence in breeding females ( J:224955 )
• pregnancy accelerates tumor formation

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:224955 )
• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance
• nearly all mice succumb to cancer by 18 months of age
increased mammary adenocarcinoma incidence ( J:224955 )
• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma
increased mammary gland tumor incidence in breeding females ( J:224955 )
• pregnancy accelerates tumor formation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory