Phenotypes Associated with This Genotype

Genotype
MGI:5752189

• Allelic Composition: Pten^tm2Mak/Pten^tm2Mak; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:224955 )

♀ • mice develop mammary tumors after a latency of 26.4 months with 70% penetrance

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 25% of mammary tumors are adenosquamous carcinoma and 4% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

♀ • pregnancy accelerates tumor formation

increased spindle cell carcinoma incidence ( J:224955 )

♀ • 4% of mammary tumors are spindle-cell/adenosarcoma

increased myoepithelioma incidence ( J:224955 )

♀ • 67% of mammary tumors are adenomyoepithelioma

integument

increased mammary gland tumor incidence ( J:224955 )

♀ • mice develop mammary tumors after a latency of 26.4 months with 70% penetrance

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 25% of mammary tumors are adenosquamous carcinoma and 4% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

♀ • pregnancy accelerates tumor formation

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:224955 )

♀ • mice develop mammary tumors after a latency of 26.4 months with 70% penetrance

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 25% of mammary tumors are adenosquamous carcinoma and 4% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

♀ • pregnancy accelerates tumor formation