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Phenotypes Associated with This Genotype
Genotype
MGI:5751562
Allelic
Composition		 Il10tm1Cgn/Il10tm1Cgn
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (43 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
rectal prolapse ( J:229155 )
• most mice develop rectal prolapse by 150 days
colitis ( J:229155 )
• severe colitis in 100% of mice; phenotype is less severe than in the presence of the intestinal endothelial cell (IEC)-specific Tlr5 null mutation

immune system
colitis ( J:229155 )
• severe colitis in 100% of mice; phenotype is less severe than in the presence of the intestinal endothelial cell (IEC)-specific Tlr5 null mutation

mortality/aging
premature death ( J:229155 )
• mice are euthanized by 5 months due to rectal prolapse

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory