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Phenotypes Associated with This Genotype
Genotype
MGI:5751557
Allelic
Composition
Tg(Vil1-cre)997Gum/?
Tlr4lps-del/Tlr4lps-del
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr4lps-del mutation (6 available); any Tlr4 mutation (94 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice do not exhibit symptoms of metabolic syndrome
• fat pad weight, body weight, spleen weight, colon weight, and fasting glucose levels are similar to wild-type

behavior/neurological

digestive/alimentary system
• increased colon weight
• low grade inflammation, however, phenotype is less severe than in mice with wild-type Tlr4

immune system
• low grade inflammation, however, phenotype is less severe than in mice with wild-type Tlr4


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory