Analysis Tools
cardiovascular system
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• at 14 weeks of age, conscious mice show significantly higher mean blood pressure than control mice throughout the day, as measured by 24-hr radiotelemetry
• however, circadian variations in heart rate are not significantly altered
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• at 14 weeks of age, conscious mice show significantly higher diastolic blood pressure than control mice throughout the day, as measured by 24-hr radiotelemetry
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• under resting conditions, conscious mice exhibit significantly higher systolic blood pressure than control mice at 8 and 22 weeks of age, as measured by the tail-cuff method
• at 14 weeks of age, conscious mice show significantly higher systolic blood pressure than control mice throughout the day, as measured by 24-hr radiotelemetry
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• mutant femoral artery rings are hyperreactive to the maximum concentration of phenylephrine (10-5 M) relative to control rings (84.1% vs 54.4% KCl contraction, respectively)
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muscle
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• mutant femoral artery rings are hyperreactive to the maximum concentration of phenylephrine (10-5 M) relative to control rings (84.1% vs 54.4% KCl contraction, respectively)
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homeostasis/metabolism
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• in primary culture, mutant aortic vascular smooth muscle cells (VSMCs) show higher intracellular calcium concentrations than control VSMCs both before (baseline) and after phenylephrine stimulation
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growth/size/body
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• mice exhibit normal body weight at 8-36 weeks of age
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