Atp2b1^tm1.1Hiraw
Targeted Allele Detail

Summary

• Symbol: Atp2b1^tm1.1Hiraw
• Name: ATPase, Ca++ transporting, plasma membrane 1; targeted mutation 1.1, Nobuhito Hirawa
• MGI ID: MGI:5703955
• Synonyms: ATP2B1^loxP
• Gene: Atp2b1 Location: Chr10:98750268-98862005 bp, + strand Genetic Position: Chr10, 50.97 cM, cytoband C3
• Alliance: Atp2b1^tm1.1Hiraw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225010
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 10. An additional loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette and left exon 10 floxed. (J:225010)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp2b1 Mutation: 65 strains or lines available

References

• Original: J:225010 Kobayashi Y, et al., Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation. Hypertension. 2012 Apr;59(4):854-60
• All: 4 reference(s)