Phenotypes for Fitm2 Lep Tg(Fabp4-cre)1Rev MGI:5707240 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Lep^ob/Lep^ob Tg(Fabp4-cre)1Rev/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fitm2^tm1.1Dls mutation (1 available); any Fitm2 mutation (22 available)
Lep^ob mutation (5 available); any Lep mutation (21 available)
Tg(Fabp4-cre)1Rev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced adiposity and unilocular lipid droplets in Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Tg(Fabp4-cre)1Rev/? Lep^ob/Lep^ob mice

growth/size/body

decreased body weight ( J:212437 )

• reduced body weight at 10 weeks relative to homozygous Lep^ob

adipose tissue

decreased subcutaneous adipose tissue amount ( J:212437 )

• at 10 weeks relative to homozygous Lep^ob

decreased white adipose tissue amount ( J:212437 )

• reduced epididymal white adipose tissue at 10 weeks relative to homozygous Lep^ob

• increased macrophage infiltration

integument

decreased subcutaneous adipose tissue amount ( J:212437 )

• at 10 weeks relative to homozygous Lep^ob

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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