Phenotypes Associated with This Genotype

Genotype
MGI:5705534

• Allelic Composition: Tg(Ggt1-tTA)#Agoc/0; Tg(tetO/CMV-PTHLH)#Agoc/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating phosphate level ( J:130310 )

• mild hypophosphatemia

• however, mice do not display hypercalcemia

renal/urinary system

renal/urinary system phenotype ( J:130310 )

N • kidney weight and morphology appears normal at 4 months of age under normal physiologic conditions and circulating markers of kidney function, BUN, and plasma creatinine concentrations are normal

N • mice exhibit a similar level of renal failure induced by ischemia/reperfusion and similar level of renal damage induced by FA injection as controls