Tg(tetO/CMV-PTHLH)#Agoc
Transgene Detail

Summary

• Symbol: Tg(tetO/CMV-PTHLH)#Agoc
• Name: transgene insertion, Adolf Garcia-Ocana
• MGI ID: MGI:5705531
• Synonyms: Teto-PTHrP
• Transgene: Tg(tetO/CMV-PTHLH)#Agoc Location: unknown
• Alliance: Tg(tetO/CMV-PTHLH)#Agoc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO/CMV-PTHLH)#Agoc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTHLH (5744)

  Pthlh

  (MGI:97800)

• Mutation details: Human PTHLH (PTHrP) cDNA is under the control of a hybrid regulatory element consisting of a heptamerized tetracycline operator (TetoX7) fused to a minimal human cytomegalovirus promoter element, followed by 3 untranslated sequences of the hGH gene. Three lines were generated however the pound (#) symbol is used because the data are pooled. (J:130310)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130310 Fiaschi-Taesch NM, et al., Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: the efficacy of parathyroid hormone-related protein and hepatocyte growth factor. J Am Soc Nephrol. 2004 Jan;15(1):112-25
• All: 1 reference(s)