About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5704425
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Mir182)Dgk/Gt(ROSA)26Sortm1(CAG-Mir182)Dgk
Krastm4Tyj/Krastm4Tyj
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Mir182)Dgk mutation (1 available); any Gt(ROSA)26Sor mutation (1062 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased metastatic potential ( J:217635 )
• 75% of mice develop lung metastases by 120 days following amputation of limb injected with cre-expressing adenovirus
• in the absence of the Gt(ROSA)26Sortm1(CAG-Mir182)Dgk allele, 43% of mice develop lung metastases
• number of number of metastatic nodules in the lung is increased compared to mice without the Gt(ROSA)26Sortm1(CAG-Mir182)Dgk allel

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory