Phenotypes for Kras Mir182 Trp53 MGI:5704424 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Kras^tm4Tyj/Kras^tm4Tyj Mir182^tm1.1Dgk/Mir182^tm1.1Dgk Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Mir182^tm1.1Dgk mutation (1 available); any Mir182 mutation (8 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased metastatic potential ( J:217635 )

• 13% of mice develop lung metastases within 6 months following amputation of limb injected with cre-expressing adenovirus

• in the absence of the Mir18^tm1.1Dgk allele, 43% of mice develop lung metastases

• number of metastatic nodules and metastatic burden in the lung are decreased compared to mice without the Mir18^tm1.1Dgk allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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