Phenotypes Associated with This Genotype

Genotype
MGI:5704414

• Allelic Composition: Hmgb1^tm1.1Dltg/Hmgb1^tm1.1Dltg; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating interleukin-6 level ( J:225260 )

• following induction of injection of L-arginine or cerulein

increased circulating tumor necrosis factor level ( J:225260 )

• following induction of injection of L-arginine or cerulein

increased circulating amylase level ( J:225260 )

• following induction of injection of L-arginine or cerulein

increased circulating lactate dehydrogenase level ( J:225260 )

• following induction of injection of L-arginine or cerulein

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:225260 )

N • mice exhibit normal pancreatic development

pancreas necrosis ( J:225260 )

• following induction of injection of L-arginine or cerulein

increased susceptibility to induced pancreatitis ( J:225260 )

• with elevated serum amylase, exaggerated acinar cell death, leukocyte infiltration, interstitial edema, worsened acute lung injury, and increased serum TNF and IL6 following induction of injection of L-arginine or cerulean

• however, administration of N-acetyl-L-cysteine or neutralization of extracellular Histone and HMGB1 protects mice

immune system

increased susceptibility to induced pancreatitis ( J:225260 )

• with elevated serum amylase, exaggerated acinar cell death, leukocyte infiltration, interstitial edema, worsened acute lung injury, and increased serum TNF and IL6 following induction of injection of L-arginine or cerulean

• however, administration of N-acetyl-L-cysteine or neutralization of extracellular Histone and HMGB1 protects mice

increased circulating interleukin-6 level ( J:225260 )

• following induction of injection of L-arginine or cerulein

increased circulating tumor necrosis factor level ( J:225260 )

• following induction of injection of L-arginine or cerulein