Phenotypes for Rb1 Trp53 MGI:5704166 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rb1^tm2Brn/Rb1⁺ Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm2Brn mutation (3 available); any Rb1 mutation (117 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor pathology ( J:86077 )

• some mice treated with a cre-expressing adenovirus exhibit metastasis in the mediastinum, ovary and adrenal gland

increased lung adenocarcinoma incidence ( J:86077 )

• in some mice treated with a cre-expressing adenovirus

increased lung small cell carcinoma incidence ( J:86077 )

• small in some mice treated with a cre-expressing adenovirus

respiratory system

increased lung adenocarcinoma incidence ( J:86077 )

• in some mice treated with a cre-expressing adenovirus

increased lung small cell carcinoma incidence ( J:86077 )

• small in some mice treated with a cre-expressing adenovirus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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