Phenotypes Associated with This Genotype

Genotype
MGI:5702670

• Allelic Composition: Hc¹/Hc¹; Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: D2.Cg-Tg(APPswe,PSEN1dE9)85Dbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

amyloid beta deposits ( J:227541 )

• Background Sensitivity: the complement pathway does not impact plaque deposition in the cortex, the number of plaques is the same as that in transgene carriers with the DBA/2J allele of Hc

behavior/neurological

convulsive seizures ( J:227541 )

• Background Sensitivity: despite the presence of functional hemolytic complement these mice have the same rate of lethal seizures as transgenics with the non-functional DBA/2J allele

mortality/aging

premature death ( J:227541 )

nervous system

nervous system phenotype ( J:227541 )

N • no significant differences are found in cortical neuron number in complement deficient versus functional transgene carriers

convulsive seizures ( J:227541 )

• Background Sensitivity: despite the presence of functional hemolytic complement these mice have the same rate of lethal seizures as transgenics with the non-functional DBA/2J allele

amyloid beta deposits ( J:227541 )

• Background Sensitivity: the complement pathway does not impact plaque deposition in the cortex, the number of plaques is the same as that in transgene carriers with the DBA/2J allele of Hc