Phenotypes for Cbfb H2az2 Mapt MGI:5702479 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm2.1Ddg mutation (1 available); any Cbfb mutation (36 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:226826 )

• reduction of sensory innervation of the epidermis at P0

abnormal axon morphology ( J:226826 )

• reduction in epidermal nerve fiber density

abnormal nociceptor morphology ( J:226826 )

• deficiency of peripheral projections of nonpeptidergic (mechanical) nociceptors

craniofacial

abnormal craniofacial development ( J:226826 )

mortality/aging

perinatal lethality ( J:226826 )

• mice die perinatally due to craniofacial defects

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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