Phenotypes Associated with This Genotype

Genotype
MGI:5699877

• Allelic Composition: Nf1^tm1Tyj/Nf1⁺; Suz12^{Gt(Betageo)1Khe}/Suz12⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal melanocyte morphology ( J:217077 )

• 9% of mice develop melanocytic nevi

mortality/aging

premature death ( J:217077 )

• 80% of mice die by 400 days

neoplasm

increased tumor incidence ( J:217077 )

• 9% of mice develop melanocytic nevi

increased intestinal adenoma incidence ( J:217077 )

• 10% of mice develop intestinal adenomas

increased hepatocellular carcinoma incidence ( J:217077 )

• 3% of mice develop hepatocellular carcinoma

increased neurofibroma incidence ( J:217077 )

• 3% of mice develop neurofibromas

increased lymphoma incidence ( J:217077 )

• 23% of mice develop lymphoma

increased histiocytic sarcoma incidence ( J:217077 )

• 32% of mice develop histiocytic sarcoma

increased neurofibrosarcoma incidence ( J:217077 )

increased Schwannoma incidence ( J:217077 )

• 3% of mice develop schwannomas

nervous system

increased neurofibroma incidence ( J:217077 )

• 3% of mice develop neurofibromas

increased neurofibrosarcoma incidence ( J:217077 )

increased Schwannoma incidence ( J:217077 )

• 3% of mice develop schwannomas

digestive/alimentary system

increased intestinal adenoma incidence ( J:217077 )

• 10% of mice develop intestinal adenomas

liver/biliary system

increased hepatocellular carcinoma incidence ( J:217077 )

• 3% of mice develop hepatocellular carcinoma