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Phenotypes Associated with This Genotype
Genotype
MGI:5699005
Allelic
Composition		 Numbtm1Zili/Numbtm1Zili
Tg(Vil1-cre/ERT2)23Syr/?
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Numbtm1Zili mutation (3 available); any Numb mutation (60 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal intestinal cholesterol absorption ( J:226578 )
• cholesterol endocytosis fails in tamoxifen treated mice
• less cholesterol absorption in liver
decreased circulating cholesterol level ( J:226578 )
• lower plasma cholesterol levels in tamoxifen treated mice
• partial resistance to diet induced hypercholesterolemia

digestive/alimentary system
abnormal intestinal cholesterol absorption ( J:226578 )
• cholesterol endocytosis fails in tamoxifen treated mice
• less cholesterol absorption in liver

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory