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Phenotypes Associated with This Genotype
Genotype
MGI:5698689
Allelic
Composition		 Mau2tm1.1Hpt/Mau2tm1.1Hpt
Nipbltm1.1Hpt/Nipbl+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Mau2tm1.1Hpt mutation (0 available); any Mau2 mutation (36 available)
Nipbltm1.1Hpt mutation (0 available); any Nipbl mutation (124 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
short mandible ( J:213338 )
• in newborn mice, the length of the mandible is 62% of that in wild-type controls, i.e. intermediate between that of mice that are singly homozygous for Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (49% of wild-type controls) and mice that are double homozygous for both Nipbltm1.1Hpt and Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (68% of wild-type controls)

skeleton
short mandible ( J:213338 )
• in newborn mice, the length of the mandible is 62% of that in wild-type controls, i.e. intermediate between that of mice that are singly homozygous for Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (49% of wild-type controls) and mice that are double homozygous for both Nipbltm1.1Hpt and Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (68% of wild-type controls)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory