Phenotypes Associated with This Genotype

Genotype
MGI:5698681

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:209928 )

increased pro-B cell number ( J:209928 )

• two fold more pro-B cells than in controls

• proliferation of c-Kit^hi pro-B cells is normal

• c-Kit^lo pro-B cells accumulate in the G1-G0 phases of the cell cycle

• cells are smaller with functionally rearranged immunoglobulin mu

• c-Kit^hi pro-B cells expressing immunoglobulin mu are increased

abnormal B cell number ( J:209928 )

• six fold reduction in total B cell number in bone marrow relative to controls

decreased pre-B cell number ( J:209928 )

• nearly complete loss of pre-B cells

neoplasm

neoplasm ( J:209928 )

N • evidence of B cell leukemias is not observed during a year of observation

immune system

abnormal B cell differentiation ( J:209928 )

increased pro-B cell number ( J:209928 )

• two fold more pro-B cells than in controls

• proliferation of c-Kit^hi pro-B cells is normal

• c-Kit^lo pro-B cells accumulate in the G1-G0 phases of the cell cycle

• cells are smaller with functionally rearranged immunoglobulin mu

• c-Kit^hi pro-B cells expressing immunoglobulin mu are increased

abnormal B cell number ( J:209928 )

• six fold reduction in total B cell number in bone marrow relative to controls

decreased pre-B cell number ( J:209928 )

• nearly complete loss of pre-B cells