Analysis Tools
vision/eye
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• newborn mice display open eyelids
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growth/size/body
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• at E10.5, the number of proliferating cells in the first branchial arch mesenchyme is reduced by ~25%
• however, the number of apoptotic cells is not significantly increased at E12.5
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• newborn mice exhibit severe facial hypoplasia
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• a mild size reduction of the upper lip is first seen at E13.5
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• an up-turned nose is first seen at E13.5
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• newborn mice have low-set ears
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embryo
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• proliferation of neural crest cells is reduced as early as E10.5; however, these cells continue to expand and are capable of differentiating into cartilage and bone, esp. in the distal region of the maxilla and mandible, respectively
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• at E10.5, the number of proliferating cells in the first branchial arch mesenchyme is reduced by ~25%
• however, the number of apoptotic cells is not significantly increased at E12.5
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craniofacial
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• all neural crest cell-derived skull components are severely affected
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• all neural crest cell-derived jaw components are severely affected
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• a mild size reduction of the lower jaw is first seen at E13.5
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• in newborn mice, the length of the mandible is 73% of that in wild-type controls
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• at E13.5
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• newborn mice exhibit severe defects in craniofacial development
• surprisingly, no gross abnormalities are noted up to E12.5
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• at E10.5, the number of proliferating cells in the first branchial arch mesenchyme is reduced by ~25%
• however, the number of apoptotic cells is not significantly increased at E12.5
|
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• newborn mice exhibit severe facial hypoplasia
|
|
• a mild size reduction of the upper lip is first seen at E13.5
|
|
• an up-turned nose is first seen at E13.5
|
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• newborn mice have low-set ears
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skeleton
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• all neural crest cell-derived skull components are severely affected
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• all neural crest cell-derived jaw components are severely affected
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• a mild size reduction of the lower jaw is first seen at E13.5
|
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• in newborn mice, the length of the mandible is 73% of that in wild-type controls
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• at E13.5
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cellular
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• proliferation of neural crest cells is reduced as early as E10.5; however, these cells continue to expand and are capable of differentiating into cartilage and bone, esp. in the distal region of the maxilla and mandible, respectively
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hearing/vestibular/ear
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• newborn mice have low-set ears
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