Phenotypes for Col1a1 Flt3 Gt(ROSA)26Sor MGI:5697542 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Col1a1^{tm2(tetO-IDH2R140Q)Ppp}/Col1a1^{tm2(tetO-IDH2R140Q)Ppp} Flt3^tm1.1Dosm/Flt3^tm1.1Dosm Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/?
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm2(tetO-IDH2*R140Q)Ppp} mutation (1 available); any Col1a1 mutation (166 available)
Flt3^tm1.1Dosm mutation (0 available); any Flt3 mutation (91 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (31 available); any Gt(ROSA)26Sor mutation (1098 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leukemia incidence ( J:210097 )

• mice treated with doxycycline develop acute leukemias

mortality/aging

premature death ( J:210097 )

• reduced overall survival of doxycycline treated mice to 229 days vs 352 days for Flt3^tm1.1Dosm controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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