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Phenotypes Associated with This Genotype
Genotype
MGI:5697531
Allelic
Composition
Auts2tm1.1Dare/Auts2tm1.1Dare
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Auts2tm1.1Dare mutation (0 available); any Auts2 mutation (63 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• knockouts showed a significantly smaller milk band at P1
• knockout mice show impairment in righting reflex relative to wild type from P3-P9, whereas heterozygotes are not impaired
• knockout mice took significantly longer to orient their nose to an upward position (turn 180o and face upwards on a slanted platform)
• knockout mice show significantly less ultrasonic vocalizations (USVs) than wild type following maternal separation across the majority of developmental time points measured

growth/size/body
• a striking visual and quantitative reduction in the body length of the knockout mice is sen relative to control littermates

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200
J:217675


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory