Phenotypes Associated with This Genotype

Genotype
MGI:5696657

• Allelic Composition: Nmt2^tm1.1Poru/Nmt2^tm1.1Poru; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:226234 )

• moderate in the thymus

• however, numbers are normal in the blood, thymus and spleen

decreased double-positive T cell number ( J:226234 )

• less so than in conditional Nmt1^tm1.1Poru and Nmt2^tm1.1Poru knock-out mice

decreased single-positive T cell number ( J:226234 )

• CD4+ and CD8+ single positive cells

hematopoietic system

decreased T cell number ( J:226234 )

• moderate in the thymus

• however, numbers are normal in the blood, thymus and spleen

decreased double-positive T cell number ( J:226234 )

• less so than in conditional Nmt1^tm1.1Poru and Nmt2^tm1.1Poru knock-out mice

decreased single-positive T cell number ( J:226234 )

• CD4+ and CD8+ single positive cells