Phenotypes Associated with This Genotype

Genotype
MGI:5696656

• Allelic Composition: Nmt1^tm1.1Poru/Nmt1^tm1.1Poru; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:226234 )

• moderate in the thymus

• in the blood, lymph nodes and spleen

decreased double-positive T cell number ( J:226234 )

• at 2 and 6 months, but less so than in conditional Nmt1^tm1.1Poru and Nmt2^tm1.1Poru knock-out mice

decreased single-positive T cell number ( J:226234 )

• CD4+ and CD8+ single positive cells

abnormal CD4-positive, alpha beta T cell morphology ( J:226234 )

• CD4+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes

abnormal CD8-positive, alpha beta T cell morphology ( J:226234 )

• CD8+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes

hematopoietic system

decreased T cell number ( J:226234 )

• moderate in the thymus

• in the blood, lymph nodes and spleen

decreased double-positive T cell number ( J:226234 )

• at 2 and 6 months, but less so than in conditional Nmt1^tm1.1Poru and Nmt2^tm1.1Poru knock-out mice

decreased single-positive T cell number ( J:226234 )

• CD4+ and CD8+ single positive cells

abnormal CD4-positive, alpha beta T cell morphology ( J:226234 )

• CD4+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes

abnormal CD8-positive, alpha beta T cell morphology ( J:226234 )

• CD8+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes