Phenotypes Associated with This Genotype

Genotype
MGI:5695464

• Allelic Composition: Srsf2^tm1Xdfu/Srsf2^tm1Xdfu; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired hematopoiesis ( J:221404 )

abnormal hematopoietic system physiology ( J:221404 )

• leukopenia is observed in bone marrow of lethally irritated recipient mice 18 weeks post-transplantation (pIpC injection 4 weeks after transplantation)

• anemia is observed 18 weeks post-bone marrow transplantation (pIpC injection 4 weeks after transplantation)

• hemoglobin is decreased donor bone marrow post-transplantation

• impaired reconstitution of hematopoietic stem/progenitor cells in peripheral blood in competitive bone marrow transplantation assay 14 weeks post-pIpC injection

• decrease in total hematopoietic stem cell (LSK) cell number in bone marrow in competitive bone marrow transplantation assay 14 weeks post-pIpC injection

• decrease in myeloid progenitor total cell number in bone marrow in competitive bone marrow transplantation assay 14 weeks post-pIpC injection

bone marrow failure ( J:221404 )

• bone marrow aplasia is observed 14 weeks post pIpC injection

immune system

bone marrow failure ( J:221404 )

• bone marrow aplasia is observed 14 weeks post pIpC injection