Phenotypes Associated with This Genotype

Genotype
MGI:5694583

• Allelic Composition: Gria2^tm1.1Bvis/Gria2^tm1.1Bvis; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: 129S6.Cg-Gria2^tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

enhanced long-term potentiation ( J:223717 )

• in CA1 after high frequency stimulation

• long term depression is unaffected

behavior/neurological

abnormal learning/memory/conditioning ( J:223717 )

• initial learning affected more than subsequent learning (NMDAR receptor vs NMDAR receptor independent)

impaired contextual conditioning behavior ( J:223717 )

• long term contextual fear conditioning is impaired

• dorsal hippocampal lesions also impair contextual fear conditioning

• pre-exposure to context fails to enhance fear conditioning

• short term memory remains intact

impaired spatial learning ( J:223717 )

• tested using a Morris water maze

abnormal long-term spatial reference memory ( J:223717 )

• impaired as tested using a radial maze

• spatial working memory not affected