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Phenotypes Associated with This Genotype
Genotype
MGI:5693797
Allelic
Composition
ApcMin/Apc+
Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (61 available)
Ccdc80tm1.1Ftk mutation (0 available); any Ccdc80 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 94 days compared to 142 days in control ApcMin heterozygotes

neoplasm
• mice develop tumors in the small intestine with no difference in number, distribution, size and histology from tumors in single ApcMin heterozygotes
• mean number of colonic tumors is 11.9 compared to 3.1 in control ApcMin heterozygotes and mice show an increase in mean tumor multiplicity in both the proximal and distal colon
• by 10 weeks of age, mice show more tumors in the colon than in single ApcMin heterozygotes, with 29% of tumors being adenocarcinoma
• no metastases to lymph nodes, liver or lungs are seen
• 35% of colon tumors are adenocarcinomas
• 97% of carcinomas are located in the distal colon
• 65% of colon tumors are adenomas

digestive/alimentary system
• vast majority of polyps localize to the small intestine
• mice develop tumors in the small intestine with no difference in number, distribution, size and histology from tumors in single ApcMin heterozygotes
• mean number of colonic tumors is 11.9 compared to 3.1 in control ApcMin heterozygotes and mice show an increase in mean tumor multiplicity in both the proximal and distal colon
• by 10 weeks of age, mice show more tumors in the colon than in single ApcMin heterozygotes, with 29% of tumors being adenocarcinoma
• no metastases to lymph nodes, liver or lungs are seen
• 35% of colon tumors are adenocarcinomas
• 97% of carcinomas are located in the distal colon
• 65% of colon tumors are adenomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
colorectal cancer DOID:9256 OMIM:114500
J:216704


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory