Phenotypes Associated with This Genotype

Genotype
MGI:5690031

• Allelic Composition: Del(16Setd4-Kcnj6)12Yey/Dp(16Lipi-Zbtb21)1Yey
• Genetic Background: B6.129S7-Del(16Setd4-Kcnj6)12Yey/Dp(16Lipi-Zbtb21)1Yey

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:224899 )

• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type

decreased exploration in new environment ( J:224899 )

• impaired performance in T maze spontaneous alteration test as compared to controls

nervous system

reduced long-term potentiation ( J:224899 )

• magnitude of hippocampal LTP following theta burst stimulation is lower than controls