Phenotypes Associated with This Genotype

Genotype
MGI:5688511

• Allelic Composition: Rbm38^tm1.1Xch/Rbm38^tm1.1Xch
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:216929 )

• median survival following exposure to 8 gray of whole body gamma-irradiation is 13 days compared to 20 days for wild-type controls

decreased tumor-free survival time ( J:216929 )

• median tumor free survival time is 94 wk compared to 121 wk in wild-type controls

• maximum lifespan is 128 wk compared to 144 wk in wild-type mice

premature aging ( J:216929 )

growth/size/body

weight loss ( J:216929 )

• at 18 months of age

enlarged spleen ( J:216929 )

• seen at 2 months of age and becomes more pronounced with age

adipose tissue

decreased total body fat amount ( J:216929 )

decreased gonadal fat pad weight ( J:216929 )

• relative percentage of gonadal fat vs. body weight is 0.4% compared to 1.8% in wild-type controls

neoplasm

increased tumor incidence ( J:216929 )

• tumors are found in 12 of 23 mice compared to 3 of 17 wild-type controls

increased hepatoma incidence ( J:216929 )

• found in 4 of 23 mice compared to 0 of 17 wild-type controls

increased lymphoma incidence ( J:216929 )

• found in 8 of 23 mice compared to 2 of 17 wild-type controls

increased hemangiosarcoma incidence ( J:216929 )

• found in 2 of 23 mice compared to 0 of 17 wild-type controls

liver/biliary system

increased hepatoma incidence ( J:216929 )

• found in 4 of 23 mice compared to 0 of 17 wild-type controls

hematopoietic system

enlarged spleen ( J:216929 )

• seen at 2 months of age and becomes more pronounced with age

extramedullary hematopoiesis ( J:216929 )

• in the spleen (in ~78% of mice) and liver (in ~26% of mice)

anemia ( J:216929 )

decreased bone marrow cell number ( J:216929 )

• erythroid hypoplasia with a relatively increased ratio of myeloid vs. erythroid lineages

increased megakaryocyte cell number ( J:216929 )

• in the spleen

abnormal erythrocyte morphology ( J:216929 )

decreased hematocrit ( J:216929 )

decreased hemoglobin content ( J:216929 )

increased spleen white pulp amount ( J:216929 )

• striking expansion

integument

spontaneous skin ulceration ( J:216929 )

• at 18 months of age

skeleton

lordokyphosis ( J:216929 )

• pronounced lordokyphosis

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:216929 )

• median survival following exposure to 8 gray of whole body gamma-irradiation is 13 days compared to 20 days for wild-type controls

immune system

enlarged spleen ( J:216929 )

• seen at 2 months of age and becomes more pronounced with age

increased spleen white pulp amount ( J:216929 )

• striking expansion