Phenotypes Associated with This Genotype

Genotype
MGI:5662410

• Allelic Composition: Mirc1^tm2.1Aven/Mirc1^tm2.1Aven; Tg(IghMyc)22Bri/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased B cell apoptosis ( J:223213 )

• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

mortality/aging

abnormal survival ( J:223213 )

• increase in survival as compared to mice carrying Tg(IghMyc)22Bri alone and mice carrying Tg(IghMyc)22Bri and heterozygous for Mirc1^tm2.1Aven

hematopoietic system

increased B cell apoptosis ( J:223213 )

• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

abnormal pre-B cell morphology ( J:223213 )

• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

immune system

increased B cell apoptosis ( J:223213 )

• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

abnormal pre-B cell morphology ( J:223213 )

• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

neoplasm

increased B cell derived lymphoma incidence ( J:223213 )

• immunophenotype of B cell lymphomas is altered (increase in in IgM+ tumors) as compared to Tg(IghMyc)22Bri alone

increased tumor latency ( J:223213 )

• as compared to mice carrying only Tg(IghMyc)22Bri