Phenotypes Associated with This Genotype

Genotype
MGI:5662394

• Allelic Composition: \Mirc1^tm1.2Tyj/\Mirc1^tm1.2Tyj
• Genetic Background: B6.Cg-Mirc1^tm1.2Tyj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

cleft palate ( J:223213 )

digestive/alimentary system

cleft palate ( J:223213 )

embryo

abnormal rostral-caudal axis patterning ( J:223213 )

growth/size/body

cleft palate ( J:223213 )

limbs/digits/tail

fused carpal bones ( J:223213 )

• all mice exhibit fusion of the proximal carpal bones

abnormal phalanx morphology ( J:223213 )

• the fifth mesophalanx of the forelimb is absent in E18.5 embryos

syndactyly ( J:223213 )

• toe syndactly

mortality/aging

perinatal lethality, complete penetrance ( J:223213 )

skeleton

fused carpal bones ( J:223213 )

• all mice exhibit fusion of the proximal carpal bones

abnormal phalanx morphology ( J:223213 )

• the fifth mesophalanx of the forelimb is absent in E18.5 embryos

vertebral fusion ( J:223213 )

• all mice exhibit vertebral fusion

vertebral transformation ( J:223213 )

thoracic vertebral transformation ( J:223213 )

• vertebra 14 is transformed from last vertebra of the rib cage into first vertebra with floating ribs (T7 to T8)

• unilateral and bilateral loss of ribs on vertebra 20 (T13 to L1a)

lumbar vertebral transformation ( J:223213 )

• transformation of vertebra 26 from last lumbar to first sacral vertebra (L6 to S1)

delayed bone ossification ( J:223213 )