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Phenotypes Associated with This Genotype
Genotype
MGI:5659950
Allelic
Composition
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1tm2Bacc
H2afvTg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Wds mutation (0 available); any Braf mutation (38 available)
H2afvTg(Wnt1-cre)11Rth mutation (3 available); any H2afv mutation (23 available)
Raf1tm2Bacc mutation (0 available); any Raf1 mutation (102 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• in 4 of 6 mice at E17.5
• mild conotruncal defects at E16.5
• in 4 of 6 mice at E17.5 with 1 mouse also exhibiting double outlet right ventricle

endocrine/exocrine glands
• in 5 of 8 mice at E16.5 and E17.5
• hypoplastic or malpositioned in 2 of 3 mice at E16.5
• hypoplastic or malpositioned in 2 of 3 mice at E16.5

craniofacial

growth/size/body
N
• mice exhibit normal embryonic crown-rump length

hearing/vestibular/ear
N
• mice exhibit normal external ear

skeleton

immune system
• in 5 of 8 mice at E16.5 and E17.5

hematopoietic system
• in 5 of 8 mice at E16.5 and E17.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cardiofaciocutaneous syndrome DOID:0060233 OMIM:115150
OMIM:615278
OMIM:615279
OMIM:615280
J:144862


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/17/2018
MGI 6.11
The Jackson Laboratory