Analysis Tools
mortality/aging
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• about 60% of mice live beyond 200 days at which point most mice carrying the transgene alone have died
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neoplasm
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• dramatic delay in tumor initiation compared to mice carrying the transgene alone
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hematopoietic system
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N |
• overall rate of protein synthesis in B lymphocytes is reduced towards normal levels unlik in mice carrying Tg(IghMyc)22Bri alone
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• B lymphocytes show increased glucose uptake and increased rate of glucose oxidation compared to mice carrying the transgene alone
• no alterations in mitochondrial mass or mitochondrial membrane potential are detected
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• dramatic increase in B lymphocytes compared to mice carrying the transgene alone
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immune system
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• B lymphocytes show increased glucose uptake and increased rate of glucose oxidation compared to mice carrying the transgene alone
• no alterations in mitochondrial mass or mitochondrial membrane potential are detected
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• dramatic increase in B lymphocytes compared to mice carrying the transgene alone
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cellular
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• dramatic increase in B lymphocytes compared to mice carrying the transgene alone
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