Analysis Tools
reproductive system
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• no changes in pubertal progression, testicular and ovarian maturation, or ovulatory dynamics are detected
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• mean litter size is increased
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nervous system
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• pituitary explants show modestly higher levels of luteinizing hormone release in response to gonadotropin-releasing hormone
• pituitary explants from females fail to decrease in LH release in response to RFRP-3 unlike in wild-type controls
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• increase in the number of Kiss1-expressing neurons in the arcuate nucleus
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homeostasis/metabolism
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• in adult males and females
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• decrease in the stimulatory effect of neurokinin B in males
• luteinizing hormones rise more slowly after orchidectomy but reach levels similar to wild-type by day 40
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• increase in the stimulatory effect of gonadotropin-releasing hormone in males
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• after a 12h fast males do not show a drop in LH levels unlike in wild-type controls but after 24h fasting LH levels are similar to controls
• after 9 weeks on a high fat diet males do not show a decrease in LH levels unlike wild-type males
• orchidectomized males fail to decrease circulating levels of LH in response to 5nmol RFRP-3 unlike in wild-type controls
• elevated levels are detected in males but not females before and during puberty
• elevated levels in females in the first 48h after ovariectomy
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growth/size/body
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• males show greater weight loss during a 24h fast
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endocrine/exocrine glands
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• pituitary explants from females fail to decrease in LH release in response to RFRP-3 unlike in wild-type controls
• pituitary explants show modestly higher levels of luteinizing hormone release in response to gonadotropin-releasing hormone
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