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Phenotypes Associated with This Genotype
Genotype
MGI:5646277
Allelic
Composition		 Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw/Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased susceptibility to neuronal excitotoxicity ( J:214805 )
• cortical neurons treated with oxidative stress inducing agents (H2O2) show reduced cell death compared to wild-type controls

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:214805 )
• cortical neurons treated with oxidative stress inducing agents (H2O2) show reduced cell death compared to wild-type controls

cellular
decreased susceptibility to neuronal excitotoxicity ( J:214805 )
• cortical neurons treated with oxidative stress inducing agents (H2O2) show reduced cell death compared to wild-type controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory