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Phenotypes Associated with This Genotype
Genotype
MGI:5646215
Allelic
Composition
Tg(Thy1-APPSw)10Jiri/0
Tg(Thy1-PSEN1*M146V)#Jiri/0
Genetic
Background
B6.Cg-Tg(Thy1-APPSw)10Jiri Tg(Thy1-PSEN1*M146V)#Jiri
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• marked amyloidosis in the thalamus, hippocampal formation and cerebral cortex
• amyloid beta deposition that appears first at about 3-4 months of age

nervous system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited
• amyloid beta deposition that appears first at about 3-4 months of age
• the brain and its component regions grow more than in wild-type mice from 6-14 months of age (5.1% vs 2.8% in wild-type), showing an increase in volume and size over time; this may be due to the progressive amyloid deposition and astrogliosis
• thalamus, cerebellum, cerebral cortex, and caudoputamen are proportionally larger from an early age in mutants than in wild-type mice but they show a relative decline with age
• thalamus and caudoputamen decline in relative volume faster than in wild-type mice, although cerebral cortex declines less rapidly
• corpus callosum, corticospinal tract, hypothalamus, midbrain-hindbrain and fornix system account for a smaller proportion of the brain, although they progressively enlarge with age similarly to wild-type mice
• corpus callosum makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age
• decrease in caudoputamen size over time (-2.8% vs. 0.1% in wild-type), even though the caudoputamen is proportionally larger at an early age in mutants than in wild-type mice
• the hypothalamus makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age
• thalamus is larger in mutants at an early age compared to wild-type mice, however the thalamus declines in relative volume faster than in wild-type mice with age
• hippocampal formation size is increased by about 11% over 8 months compared to about 0.3% in wild-type mice
• a 2.4% increase in cerebral cortex size compared to a -0.4% decrease in wild-type mice over time
• cerebellum is larger in mutants at an early age compared to wild-type mice, however a decline in size is seen with age as in wild-type mice
• astrogliosis in the cerebral cortex, thalamus, and hippocampal formation at 9-14 months of age
• the corticospinal tract makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age

hematopoietic system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited

immune system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:604154
OMIM:608907
J:156577


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory